What caused the ORPH.IR stock volume spike today?

The spike likely reflects targeted trading interest in Open Orphan Plc tied to contract or trial news expectations. ORPH.IR stock traded **15,112.00** shares pre-market versus a **192.00** average, suggesting a concentrated burst rather than broad sector flows.

How does ORPH.IR stock valuation compare to peers?

ORPH.IR stock shows a PE of **7.80** and PB of **1.86**, below the Healthcare sector PE near **31.04**, indicating a relative valuation discount. Investors should check cash, contract backlog and trial milestones before valuing the gap.

What is Meyka AI's forecast for ORPH.IR stock?

Meyka AI's forecast model projects **€0.24** for ORPH.IR stock over 12 months, implying **71.43%** upside from **€0.14** today. Forecasts are model-based projections and not guarantees.

Should traders enter on the volume spike in ORPH.IR stock?

Active traders may use the spike if volume sustains above **2,000.00** daily and price breaks **€0.16** with depth. For buy-and-hold investors, wait for confirmatory company updates or improved liquidity.

EU Stocks

ORPH.IR volume spike Open Orphan (EURONEXT) pre-market 25 Feb: liquidity rising

ByHuzaifa Zahoor February 25, 2026February 25, 2026

A pre-market volume spike in ORPH.IR stock is the main mover today, with 15,112.00 shares traded versus an average of 192.00. Open Orphan Plc (ORPH.IR) on EURONEXT opened at €0.14 and shows a sharp relative volume of 78.71, signalling renewed market attention ahead of any formal updates. We examine valuation, balance-sheet metrics and short-term trading implications for Europe-listed Open Orphan Plc using Meyka AI’s real-time data and market context.